SCOPE Trial
The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-Cardiac for Postoperative Delirium
Project Overview
This multisite randomized controlled trial aims to revolutionize post-cardiac surgery care by testing a novel intervention bundle against current protocols. The study involves 406 cardiac surgery patients, evaluating whether our Sleep, Cognition, and Pain (SCOPE) optimization approach better prevents postoperative delirium compared to the standard Enhanced Recovery After Surgery (ERAS) protocol.
Clinical Significance
Postoperative delirium is a common surgical complication in older adults. This condition can lead to significant memory and thinking deficits, and is associated with increased risk of cognitive decline and development of Alzheimer’s disease and related dementias.
The SCOPE Bundle
Our intervention combines three key components:
- Scheduled intravenous acetaminophen administration over 48 hours
- Cognitive behavioral therapy for insomnia (CBT-I)
- Cognitive training through brain puzzles
Our Aims
Prevent
Postoperative delirium
Determine differences in key patient-centered postoperative outcomes
Evaluate implementation barriers for our SCOPE bundle
Expected Outcomes
This research aims to establish a more effective protocol for preventing postoperative delirium, potentially transforming standard care practices for cardiac surgery patients and improving long-term cognitive outcomes in older adults.